Tuesday, December 29, 2009

James Beard Meatloaf; nothing better

I have used this recipe for more than 50 years. This is basic meatloaf. Note there is no tomato gunk over the top.

The changes I make are probably not significant.
1. Microwave the veggies first to soften
2. Panko breadcrumbs
3. Forget the bacon. Gave that up in the 1970's
4. I use 3 lbs meat. Just enough to fill Pan Loaf.
5. Over night chill.
in reference to: astray recipes: James beard's meatloaf (view on Google Sidewiki)

Tuesday, December 22, 2009

An Expert can Miss the Point

Accept Defeat: The Neuroscience of Screwing Up | Magazine: "Modern science is populated by expert insiders, schooled in narrow disciplines. Researchers have all studied the same thick textbooks, which make the world of fact seem settled. This led Kuhn, the philosopher of science, to argue that the only scientists capable of acknowledging the anomalies — and thus shifting paradigms and starting revolutions — are “either very young or very new to the field.” In other words, they are classic outsiders, naive and untenured. They aren’t inhibited from noticing the failures that point toward new possibilities."

Wednesday, December 9, 2009

Cocaine addiction may be solved in another decade; oops!

12 years after I had published with Richard Rothman, an employee of NIDA that cocaine addiction could be immediately stopped by the predecessor of PURSOR, Eric Nestler, using NIDA grant money stated:
"Effective medications for treating cocaine addiction will eventually be developed, and the best strategy for progress in this area is to target neurobiological mechanisms, such as those described above. Although the process takes a very long time—it can take 10 to 20 years to advance from identification of a disease mechanism to development of a new treatment—this work is in progress and represents the best hope for those who are addicted."

Wednesday, December 2, 2009

Decreased Frontal Lobe Activity in Addicted and Attention Deficit

 Nora Volkow, the current director of the National Institute on Drug Addiction (NIDA),  reviewed in 2005 the various protocols that are in use today to evaluate brain function in the addicted subject.
Modern imaging techniques enable researchers to observe drug actions and consequences as they occur and persist in the brains of abusing and addicted individuals.
The frontal cortex (blue in the image) is a brain region that supports logical thinking, goal setting, planning, and self-control. Numerous studies have documented that addictive drugs cause volume and tissue composition changes in this region and that these changes are likely associated with abusers’ cognitive and decisionmaking problems.
Incidentally, similar changes occur in the brains of those suffering from ADD and ADHD.

The addicted individual must abstain from drugs for weeks to months before the frontal hypofunction resolves.  It would be of interest to see whether such resolution occurs shortly after the administration of the PURSOR protocol and the resultant resolution of craving.

Wednesday, November 25, 2009

Does neuroinflammation fan the flame in neurodegenerative diseases and autism?

The following quotation comes from a review article that is being published this month.

"While peripheral immune access to the central nervous system (CNS) is restricted and tightly controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety of insults. Infections, trauma, stroke, toxins and other stimuli are capable of producing an immediate and short lived activation of the innate immune system within the CNS. This acute neuroinflammatory response includes activation of the resident immune cells (microglia) resulting in ... the release of inflammatory mediators such as cytokines and chemokines. Chronic neuroinflammation is a long-standing and often self-perpetuating  response that persists long after an initial injury or insult. ... The sustained release of inflammatory mediators works to perpetuate the inflammatory cycle, activating additional microglia, promoting their proliferation, and resulting in further release of inflammatory factors.

Neurodegenerative CNS disorders discussed are multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS)."(REF/ FULL TEXT)
Researchers are becoming aware that  autism is another neuroinflammatory condition that can be triggered in animal experiments. Terbutaline, a bronchodilator also used to arrest preterm labor, has been associated with the development of human autism. In animal experiments, terbutaline given early, also induce a condition that appears to be like autism. Neuroinflammation, mostly associated with innate immunity, characterized by activation of microglia and astroglia, as well as increased cytokines and chemokines, has recently been documented in post mortem studies of autism brains and in the animal damaged by neuroinflammation.(REF/FULL TEXT)

Another 2009 article that reinforces the suggestion that autism and neurodegenerative diseases are central nervous system autoimmune diseases skewed towards a proinflammatory bias :

This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD.
Finally, Paul Ashwood writes this. I would highly recommend you read the full text of his article:
Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped behaviors. At the present time, the etiology of ASD is largely unknown, but genetic, environmental, immunological, and neurological factors are thought to play a role in the development of ASD. Recently, increasing research has focused on the connections between the immune system and the nervous system, including its possible role in the development of ASD. These neuroimmune interactions begin early during embryogenesis and persist throughout an individual's lifetime, with successful neurodevelopment contingent upon a normal balanced immune response. Immune aberrations consistent with a dysregulated immune response, which so far, have been reported in autistic children, include abnormal or skewed T helper cell type 1 (T(H)1)/T(H)2 cytokine profiles, decreased lymphocyte numbers, decreased T cell mitogen response, and the imbalance of serum immunoglobulin levels. In addition, autism has been linked with autoimmunity and an association with immune-based genes including human leukocyte antigen (HLA)-DRB1 and complement C4 alleles described. There is potential that such aberrant immune activity during vulnerable and critical periods of neurodevelopment could participate in the generation of neurological dysfunction characteristic of ASD.
Damage or Disruption?

The PURSOR protocol has been extremely effective in ALS. It may be that irreversible changes occur in the child with autism. However, if the changes are not permanent, neuroinflammation and the autistic behavioral abnormalities may very well be remitted with PURSOR.

Monday, November 23, 2009

Results from PURSOR Survey

The PURSOR Follow up has been completed by 4 of the 12 persons sent the survey.

3/4 are still using PURSOR
The 1 person not taking PURSOR stated that the reason for stopping is the cost

4/4 are very satisfied with their response

3/4 said that their psychological improvement was similar to the response in the bar graph above. The other said it was "somewhat".

Thanks to those responding. I would appreciate hearing from anybody who has taken PURSOR for more than two weeks. . The survey is here. Anybody who wants can look at the survey, I just ask you not to participate. Please feel free to phone or email me if you have any questions.

The practitioners who have prescribed PURSOR have been notified of these results but no names have been disclosed to them or anybody else.

Pietr Hitzig, M.D.
Baltimore, MD
Google Site: http://foxyurl.com/7Bh
Blog: http://foxyurl.com/KfE
PowerPoint: http://bit.ly/2UbPrN
443 231-6240

Sunday, November 22, 2009

Common Pathways of Abused Substances; All Lead to Dopamine

There is an excellent diagram in Nature Neuroscience that shows how the various drugs of abuse share a common pathway, usually starting in the ventral tegmental area and progressing to the dopamine neurons in the nucleus accumbens.

This highly technical article accentuates the point that all substances of abuse increase dopamine, remove pain and promote pleasure. The PURSOR protocol also increases dopamine but rather than increasing it very rapidly, does it relatively slowly, seconds vs. milliseconds. PURSOR relieves the psychic pains of low dopamine but provides no rush of pleasure. It therefore is not addictive.

Friday, November 20, 2009

Lyme Arthritis: Current Concepts and a Change in Paradigm

The ability of B. burgdorferi, the spirochete responsible for Lyme Arthritis, to avoid clearance by the immune system may be attributed in part to an inadequate innate immune response upon infection. However, innate cells such as monocytes, macrophages, and dendritic cells display a vigorous response against borrelial infection and play a major role in the activation of the adaptive immune response against the spirochete. Despite these efforts, though, arthritis still develops in a significant number of patients infected with B. burgdorferi. It appears that the robust response elicited by monocytes, macrophages, and dendritic cells against the spirochete may be viewed as insufficient in early infection but excessive in the later stages. Paradoxically, in mounting such a strong defense against the organism, these cells may inadvertently be contributing to the induction of Lyme arthritis.

Lyme disease is associated with a chronic inflammatory bias with excessive T helper 1 cytokines. This condition has responded to PURSOR therapy in a Rhode Island lady who had not responded to antibiotic treatment at Yale under the care of my medical school classmate Allen Steere who has deservedly earned a reputation in this field.

Lyme Arthritis: Current Concepts and a Change in Paradigm

Tuesday, November 17, 2009

A Wide Specrum of Maladies are Associated with Immune Imbalance

I have a strong belief that the PURSOR protocol can correct the basic imbalance in both the innate and adaptive immune systems. I have compiled a list of just some of the many conditions whose symptoms and signs are directly associated with this imbalance. You can find at this site a new type of bibliography that I have created at the National Library of Medicine. One can retrieve all the references and then select whether you wish to select all the review articles or those articles with free full texts

Many investigators have postulated that were we to correct this underlying imbalance, commonly referred to as biased Th1/Th2 cytokine dysregulation, the chance of a remission would be likely I offer here two relevant and well-written articles. Moss, R.B. et al (2004) and Lucey, Clerici, & Shearer (1996).

Monday, November 16, 2009

Another Fine Sample of Balanced Polymorphism: No Bad Genes

Andrew Sullivan points out in the Daily Dish:

The Atlantic has a wonderful article in the new issue by David Dobbs on how the same genes can be advantageous or debilitating:
Gene variants generally considered misfortunes (poor Jim, he got the "bad" gene) can instead now be understood as highly leveraged evolutionary bets, with both high risks and high potential rewards: gambles that help create a diversified-portfolio approach to survival, with selection favoring parents who happen to invest in both dandelions and orchids.
In this view, having both dandelion and orchid kids greatly raises a family's (and a species') chance of succeeding, over time and in any given environment. The behavioral diversity provided by these two different types of temperament also supplies precisely what a smart, strong species needs if it is to spread across and dominate a changing world. The many dandelions in a population provide an underlying stability. The less-numerous orchids, meanwhile, may falter in some environments but can excel in those that suit them. And even when they lead troubled early lives, some of the resulting heightened responses to adversity that can be problematic in everyday life--increased novelty-seeking, restlessness of attention, elevated risk-taking, or aggression--can prove advantageous in certain challenging situations: wars, tribal or modern; social strife of many kinds; and migrations to new environments. Together, the steady dandelions and the mercurial orchids offer an adaptive flexibility that neither can provide alone. Together, they open a path to otherwise unreachable individual and collective achievements.

Sunday, November 15, 2009

Psychoneuroimmunology and the Renaissance of "Balance is Health; Imbalance is Illness and Pain"

For more than two millennia, the concept that imbalance was basic to most disease processes was accepted in both Eastern and Western medicine.
  • The Hippocratic school held that all illness was the result of an imbalance in the body of the four humours, fluids which in health were naturally equal in proportion (pepsis).[25] When the four humours, blood, black bile, yellow bile and phlegm, were not in balance (dyscrasia, meaning "bad mixture"), a person would become sick and remain that way until the balance was somehow restored. Hippocratic therapy was directed towards restoring this balance. For instance, using citrus was thought to be beneficial when phlegm was overabundant (Wiki),
  • Traditional Chinese medicine is largely based on the philosophical concept that the human body is a small universe with a set of complete and sophisticated interconnected systems, and that those systems usually work in balance to maintain the healthy function of the human body(Wiki)
As Western medicine matured, it gained tools such as the microscope, petri dish and many more and just as Linneau at the peak of the enlightenment classified plants,so did other classify the various illnesses. This was all to the good. But as knowledge progressed and amazing leaps in medical therapy  were made, a new medical paradigm was developing.

When I was in high school  in the late '50s, I was an avid reader and regularly reviewed Scientific American. I witnessed in the field of nuclear physics an explosion of particles that were derived from the atom. When the number surpassed 35 I gave up reading any more. Just as Italian politics at that time, when prime minister were coming and going nearly on a weekly basis. Too many prime ministers and too many particles told me even in my adolescence that something was wrong in theoretical physics and in Rome. Murray Gell-Mann and George Zweig introduced the quark and brought some order, Bellasconi still proves that Italy can not govern itself. Western medicine has evolved  Although Descartes supported mind-body duality and saw the body as an automaton run by the brain, he did recognize that the body could influence the brain. Unfortunately, while most physicians pay lip service to Hans Selye's concept of stress, most continue to practice medicine as if the unitary link between mind and body did not exist.

The following are landmarks in the development of psychoneuroimmunology:

Homeostasis (from Greek: ὅμοιος, homoios, "similar"; and ἵστημι, histēmi, "standing still"; defined by Walter Bradford Cannon in 1929 + 1932 is the property of a system, either open or closed, that regulates its internal environment and tends to maintain a stable, constant condition. Typically used to refer to a living organism, the concept came from that of milieu interieur that was created by Claude Bernard and published in 1865 (Wiki)

Hans Selye's inspiration for the general adaptation syndrome (GAS, a theory of stress) came from an endocrinological experiment in which he injected mice with extracts of various organs. He at first believed he had discovered a new hormone, but was proved wrong when every irritating substance he injected produced the same symptoms (swelling of the adrenal cortex, atrophy of the thymus, gastric and duodenal ulcers). This, paired with his observation that people with different diseases exhibit similar symptoms, led to his description of the effects of "noxious agents" as he at first called it. He later coined the term "stress", which has been accepted into the lexicon of various other languages.(Wiki)

In 1964, George F. Solomon, published "Immunity, emotions and stress. With special reference to the mechanisms of stress effects on the immune system" and birthed the field of psychoneuroimmunology. In the next thirty years multiple articles proving that stress, modifying the immune system was directly linked to  illness not only psychologic but also physical. No longer could the various infirmities that plague us exist in their solitary splendor or decay but could be linked into a common structure resulting from an imbalanced immune system. Diseases are not to be classified like plants but are intimately linked with each other.

In the near future, I plan to write a section that shows how diseases are linked by the bias of the cytokines that are associated with them. I will show that the development of T helper cell (Th) imbalances of the subsets Th1 and Th2 reciprocal systems are the not markers for disease but the causative factor.

Finally, I would suggest that you review RB Moss's fine article that reviews the multiple conditions that are associated with imbalances of Th1 and Th2 cells. Moss suggests a couple of methods to restore this imbalance and his approach, especially with DNA  vaccinations, may prove to be invaluable.My contention in this unpublished article that the PURSOR protocol can achieve a similar balance needs to be proven, but if it can, WOW.

Wednesday, November 11, 2009

Against Excessive Skepticism: Collected Quotes

"'If I want to stop a research program I can always do it by getting a few experts to sit in on the subject, because they know right away that it was a fool thing to try in the first place.' - Charles Kettering, GM"

This and many more quotations that scientists do not countenance new ideas or paradigms can be found here.

Saturday, October 31, 2009

New Concepts, Dangerous Beasts Slouching

The Second Coming

TURNING and turning in the widening gyre
The falcon cannot hear the falconer;
Things fall apart; the centre cannot hold;
Mere anarchy is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
The best lack all conviction, while the worst
Are full of passionate intensity.

Surely some revelation is at hand;
Surely the Second Coming is at hand.
The Second Coming! Hardly are those words out
When a vast image out of Spiritus Mundi
Troubles my sight:  somewhere in sands of the desert
A shape with lion body and the head of a man,
A gaze blank and pitiless as the sun,
Is moving its slow thighs, while all about it
Reel shadows of the indignant desert birds.
The darkness drops again; but now I know
That twenty centuries of stony sleep
Were vexed to nightmare by a rocking cradle,
And what rough beast, its hour come round at last,
Slouches towards Bethlehem to be born?

Author: William Butler Yeats
Online Poetry at PoetryFeast.com

Wednesday, October 28, 2009

Dopamine is irresistible to everything but serotonin

Natalie Angiers in the New York Times discusses in a trenchant and amusing fashion how dopamine is essential to motivate us to action. She neglects to point out that serotonin is the neurotransmitter that tells us when to stop. Jonah Lehrer complements her article on the Frontal Cortex website.

Here are my comments:

The addicted patient seeks dopamine not only to give pleasure but to relieve the pain of dopamine deficit. Unfortunately, increasing dopamine can itself be addictive or as Richard Pryor put it, "Cocaine makes a new man out of me and the new man wants cocaine." Fortunately, actually inevitably, there is a neurotransmitter that inhibits behavior, serotonin.

In 1993, I introduced Dr. Richard Rothman, director of National Institute of Addiction's Intramural Research Program in Baltimore, to the idea that combined dopamine and serotonin agonists
(CODAS) could treat addiction and other disorders. I have gone on and used levodopa and 5-HTP the precursors of dopamine and serotonin, as the best way to manage same. Richard has gone in another direction. In this recent article he reviews the rationale behind CODAS and the dual deficit model of addiction and discusses the development of an agent that can do this effectively.

Tuesday, October 20, 2009

Why 5-HTP and the PURSOR Protocol May Improve Parkinson's Disease Rx


The inevitable progression of Parkinson’s Disease (PD) is unresponsive to treatment. Dopamine (DA) agonists may promote the underlying neurodegenerative process. Combined 5‑hydroxytryoptophan (5-HTP), the immediate precursor of serotonin (5-HT), and levodopa therapy should block DA induced PD progression because DA and 5­­-HT have countervailing actions in the immune system. While DA promotes inflammatory Th1 cytokines, neurotoxicity and neural apoptosis (programmed cell death), 5-HT promotes anti-inflammatory Th2 cytokines, acts as a neuroprotectant, and is antiapoptotic. Combined DA and 5-HT precursor therapy (PURSOR) with levodopa and 5-HTP suspensions titrated by taste, already associated with unprecedented partial remissions in another neurodegenerative disorder, amyotrophic lateral sclerosis, should markedly improve symptomatic Parkinson’s treatment, decrease the incidence of levodopa toxicity, and, by restoring Th1/Th2 balance and putatively decreasing QUIN induced excitatory neurotoxicity, alleviate or even halt the progression of PD.

Seven Reasons:

A.      The buccal mucosal route permits both precursors to pass through the blood-brain barrier directly without first passing through the general circulation. Since this markedly diminishes the decarboxylation of either precursor prior to its entering the CNS, carbidopa is no longer necessary.
B.       Maximum therapeutic levodopa doses to assuage nigrostriatal DA deficiency should now be realized promptly and safely. Prior to the proprietary PURSOR protocol, the responsible clinician, concerned that increasing the levodopa dose could at any time induce severe adverse effects, knowing that the only clinical endpoints were the onset of levodopa toxicity or PD clinical improvement, recognizing there was no procedure to ameliorate levodopa toxicity except the passage of time, increased levodopa dosage slowly and gingerly. One can assume that many a PD patient never achieves maximal levodopa intervention because of this understandable concern. The PURSOR protocol permits one to increase levodopa more acutely since the administration of 5-HTP reverses the toxic symptoms of levodopa excess
C.      The neurotoxicity associated with PD and increased by levodopa administration presumptively can be reversed by the increase of 5-HT, a glutamate antagonist and a neuroprotectant with the ability to diminish excessive QUIN toxicity and cellular apoptosis associated with hyperstimulation.
D.      The PURSOR protocol, by promoting CNS 5-HT levels, should decrease or ablate the Th1>Th2 imbalances associated with autoimmune disorders and suppress or halt the underlying neurodegenerative PD process.
E.       The unprecedented and rapid partial remissions noted by patients with ALS treated with the PURSOR protocol strongly suggests that 5-HT is modulating the EAA-associated neurotoxicity endemic in neurodegenerative disorders.
F.      Approximately 15% of DA treated PD patients develop obsessive/compulsive disorders. The addition of 5-HT to the regimen potentially ablates this as a problem.
G.       PD destroys both dopaminergic and serotoninergic cells. If for no other reason, the joint administration of both 5-HT and DA precursors makes empiric sense.

(Full text) More Formal Presentation

Monday, October 19, 2009

Introduction to Immune disorders and their treatment with PURSOR


In my opinion, the neurotransmitters dopamine (DA) and serotonin (5-HT) are the primary regulators of life. These two similar substances control in a reciprocal fashion not only human beings but also all other animal species. More than two millennia ago both the Chinese and the Greeks recognized that "balance is health; imbalance is illness and pain." In summary, DA greatly resembles the Yang and 5-HT the Yin. Western medicine started to recognize this antipodal action in 1957.

Multiple articles in the current medical literature discuss imbalance in the T helper cells. T helper cells are simplistically divided into two major divisions, Th1 and Th2 cells. Harvard's Dr. Kimball summarizes this far better than I can. I would strongly recommend this link. Let's focus on the two major components.
  • The cellular immune system (Th1 driven, Th2 opposes) (increased by DA, suppressed by 5-HT) goes to work when it senses a foreign cell threatening our well-being. These foreign cells can arise from the outside, from viruses and bacteria whose survival inside our body is at the expense of our health or even our survival. This cellular system can also be activated to fight our own cells that have mutated and threaten us with cancer and similar diseases.
  • The humoral system (Th2 driven, Th1 opposes) (increased by 5-HT, suppressed by DA)   becomes activated when it senses that there are foreign proteins threatening to overwhelm us. The humoral system produce antibodies that can safely engulf these foreign chemicals and dispose of them safely.
Interestingly enough, each system controls the other. The cellular system reins in the humoral and the humoral keeps the cellular in control. Th1 suppresses Th2 and Th2 suppresses Th1

Unfortunately, when we are diseased, one or the other system can break out of control and start to overact. If the cellular system excessively dominates, doing its job too well, It starts to attack our own good cells and autoimmune diseases such as lupus, rheumatoid arthritis, psoriasis and Lyme disease ravage our bodies. In the brain, the cellular system running amok can cause neurodegenerative conditions such as Lou Gehrig/s disease or multiple sclerosis that rot our brain and spinal cord.. This is Th1 excess.

Th2 excess conditions, when the humoral system is too vigilant and the body reacts to unimportant levels of foreign protein, are allergic in nature. Asthma, allergic shock, hives and food allergies can cause us woe.Th2 excess.

By the year 2002 there had been already 200 patent applications to bring such imbalances under control. Those folks were looking to create a harmonious equality of the humoral and cellular immune systems or, in fancy terms, a Th1/Th2 balance. The treatments covered in these patent applications shared, in most cases, three qualities. They were toxic, expensive, and ineffectual.

Fortunately, It is apparent when one reads the medical literature that brain dopamine and serotonin controls the Th1/Th2 ratio and can restore it to balance.

  • Dopamine increases TH1 and controls Th2 
  • Serotonin increases Th2 and diminishes Th1. 
Why not, you may ask, don't we correct the Th1/Th2 imbalance and remit illness by increasing the brain levels of dopamine and serotonin?

The administration of the PURSOR protocol which permits our own brain to bring dopamine and serotonin into balance permits us to control either immune system that is overeager and bring us into balance. It is not surprising that when we bring the Th1 and Th2 under control that autoimmune, neurodegenerative, and allergic conditions can remit and stay away as long as the treatment is given.

Immunodeficient conditions are a bit, just a bit, more complicated. In such conditions both the cellular and humoral systems are damaged. I believe, however, with the restoration of proper dopamine and serotonin levels, these conditions  will also improve. I have seen a phenomenal success with an AIDS patient, but that is another story.

Technical section below. Click on title to get full text.

The Restoration of ImmuneTh1/Th2 Balance with Combined Dopamine and Serotonin Agonists

Pietr Hitzig, M.D.

443 231-6240

Sunday, October 18, 2009

Combined dopamine and serotonin precursor protocol remits addictive craving & immune disorders


I have found that the contemporaneous administration of the precursors for dopamine and serotonin has widespread therapeutic applications. Using sequential suspensions of levodopa and 5-HTP when administered according to what I call the PURSOR (patent applied for) protocol, one can remit addictive craving, mood disorders and correct certain immune disorders. If interested, you can review my thoughts on PURSOR and the immune system and my thoughts on why this approach for Parkinson's disease may be most rewarding.

The PURSOR protocol employs a serendipitous finding. Both of these precursors in suspension with flavoring agents are at the onset initially pleasant. Continued administration and each suspension becomes bland to taste and then unpleasant. The loss of pleasant taste appears to correlate with repair of the inherent CNS deficiency. Incidentally, you can also produce this phenomenon at home by mixing a 0.5 tablespoon or so of MSG. (sold as Accent in the USA) with a third of a packet of an artificial sweetener. Dip a wetted finger in the powder and it is sweet. Continue to do so and it becomes salty and not pleasant. Why this happens I do not know.

PURSOR Procedure and Protocol

I leave the exact formulation for PURSOR with the formulating pharmacy in California, but this is the general idea.
  • For the 5-HTP admixture one combines powdered 5-HTP with an oil. A simple sugar syrup is added, it has an inherent pleasant taste. Other inert materials suggested by the formulating pharmacist are added. This is placed in a 30cc. bottle
  • For the levodopa, same thing. Also added is an artificial sweetener and tangerine flavoring, etc. This is placed in a 30 cc. opaque bottle and refrigerated. Levodopa oxidizes readily.
Prior to use, each bottle is shaken. 3 drops or so at a time of the 5-HTP suspension is dropped on a spoon and licked off. Back of the hand also works. Usually, this suspension is pleasant at first. Rarely, the first aliquot is mean and nasty. Continue with further aliquots until taste changes to bland. If you continue it becomes unpleasant. Should you ignore this change with either precursor, nausea and vomiting follows. The addition of a bitter substance seems to make the endpoint more noticeable.

After the 5-HTP endpoint is achieved, do the same with the levodopa suspension. The whole sequence takes about 3 minutes Were the patient craving alcohol or cocaine, severely depressed and anxious and suffering from asthma, in a moment all these disorders remit. When craving or the other conditions return, they can be effectively managed by repeating the procedure. 2-3 times a day usually suffices. The response rate for craving alcohol, methamphetamine and cocaine is nearly 100% and nearly the same for affective disorders and immediate hypersensitivity. The preliminary results with opiates is promising.

Some patients find only one suspension pleasant. I have interpreted this to mean that there is no inherent CNS deficit for this particular neurotransmitter. Control patients rarely have found both to be unpleasant from the start.

You urge the patient to swish the suspensions around in the mouth as long as possible. Since they don't spit, they swallow the residual.

Were you to immediately swallow, the respective precursors would be absorbed in the alimentary tract, pass first through the liver and be there decaboxylated to either DA or 5-HT. Absorption through the buccal and lingual mucosa permits the first pass to the brain. No need for a decarboxylase inhibitor such as carbidopa.

Addictive Craving

In 1993, I introduced Dr. Richard Rothman, director of NIDA's Intramural Research Program in Baltimore, to the idea that combined dopamine and serotonin agonists (CODAS) could treat addiction and other disorders. I have gone on and used levodopa and 5-HTP (PURSOR) as the best way to manage same. Richard has gone in another direction. In this recent article, he reviews the rationale behind CODAS and discusses his recent work.

Sample Results

Recently, in a two week period, practitioners in Colorado and Sacramento started PURSOR on seven new patients. All but one of them were craving either alcohol, cocaine or methamphetamine. All but two of them were suffering from anxiety and/or depression. In every case, the patients enjoyed total relief of craving and their mood disorders in minutes. The return of any of their symptoms (craving or dysphoria) signals the need for the next treatment. One patient is enjoying total relief from his chronic rhinitis. He is letting his stuffy nose tell him when he should take the next dose.
  • You may wish to review a brief PowerPoint Presentation).

Pietr Hitzig, M.D.
Baltimore, MD
Google Site: http://foxyurl.com/7Bh
PowerPoint: http://bit.ly/2UbPrN
443 231-6240

Sunday, October 11, 2009

Comfort from Kuhn

Why science abhors revolutionary ideas is delineated by Stephen Kuhn's The Structure of Scientific Revolutions. In this book, Kuhn created the neologism, "Paradigm shift."

Friday, January 2, 2009


From my mother's sleep I fell into the State,
And I hunched in its belly till my wet fur froze.
Six miles from earth, loosed from the dream of life,
I woke to black flak and the nightmare fighters.
When I died they washed me out of the turret with a hose.