Superstimulation and the derangement of tryptophan metabolism

Streptococcus pyogenes may cause tonsillitis, scarlet fever and so-called “streptococcal toxic shock-like syndrome” (STSS). These streptococci produce exotoxins which are implicated as superantigens in the pathogenesis of STSS and scarlet fever. Such toxins were shown to induce neopterin production and tryptophan (TRP) degradation and cause hyperstimulation of the Kynurenic pathway. The production of the enzyme IDO (indoleamine (2,3)-dioxygenase) is promoted by interferon-gamma. IDO promotes TRP being shunted down the kynurenic pathway and the production of excitatory dopaminergic neurotoxins such as Quinolinate. Furthermore, since inadequate amounts of TRP are not passing down the serotonin pathway, decreased serotonin production lessens its ability to inhibit Interferon-gamma, also stimulated

Both generations of the CODAS protocol, fen/phen and PURSOR have been successful in remitting acute viral syndromes including the flu. REMEMBER, 5-HT inhibits INF-gamma and the resulting paucity prevents sufficient production of IDO which trips off TRP degradation.

The same basic concept is central in HIV’s ability to initiate immunodeficiency by superstimulating the immune system thru INF-gamma and the production of IDO and the subsequent immunodeficiency and neurotoxic metabolite of the kynurenic pathway, Quinolinic acid. CODAS has remitted terminal HIV.

The most widely propagated etiology for winter colds is because more people from outside the community commingle at such times. I believe that the immune system in winter is weakened by monoamine deficiencies associated with less light.