The monoamines dopamine and serotonin v. glucocorticoids as the first regulators of stress

Sapolsky in this superb article discusses the damage that uncontrolled stress can do. He promotes the mainline hypothesis that corticosteroids are the primal regulators. I think there is a far more primitive reciprocal regulatory system:

• The structures of both levodopa and serotonin are far simpler than glucocorticoids. 
• The metabolite pathways for both monoamines are far simpler; both are only 2 steps from essential amino acids. 
• Both TYRosine and TRYptophan are first hydroxylated and then decarboxylated to achieve their endpoints, DA and 5-HT. 
• The enzymes for both are either identical (L-aromatic amino acid decarboxylase) or were identical in the past. 

Sleep Apnea: An immune disorder

The conventional wisdom is that sleep apnea (SA), a condition that more than 5% of the American population and is associated with markedly increased risk of heart attacks and strokes, is a mechanical disease. Those with it are frequently overweight with short and thick necks. However, there is increasing evidence that SA is another immune disorder associated with inflammation. Inflammation and sleep apnea I strongly believe that PURSOR would remit SA. Do look at this review: serotonin rx of same

Severe allergies and celiac disease respond to treatment and didn't come back

This a recent review of celiac disease immunology. I have found that the combination of dopamine and serotonin precursors utilizing the PURSOR protocol has astounding therapeutic capabilities. Dopamine and 5-HT have reciprocal action, the former promotes Th1 and reigns in Th2 and the latter does the contrary. The PURSOR protocol seems to have the ability to restore Th1/Th2 balance. A patient with celiac disease did respond. Interestingly, she presented with life-threatening idiopathic anaphylaxis which not only also had total recovery but has been in remission for more than 10 years. Apparently, celiac and immediate hypersensitivity disorders do coexist.

In simpler words. Immune diseases are divided into allergies and autoimmune. Celiac disease is an autoimmune. Severe allergies lead to allergic disasters (anaphylaxis). This patient had both types of illness, responded to treatment and has never had a recurrence.

Could TH1 and TH2 diseases coexist? Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis: a register study